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Meeting 2018 TMS Annual Meeting & Exhibition
Symposium Bio-nano Interfaces and Engineering Applications Symposium
Presentation Title Biomolecular Design of Soft Interfaces for Technology and Medicine
Author(s) Mehmet Sarikaya
On-Site Speaker (Planned) Mehmet Sarikaya
Abstract Scope Predictably interfacing biomolecules with solids is the key for drug delivery, enzyme immobilization, implant biofunctionalization, and biochemical-sensors plus cell behavior and remineralization. Highly specific interactions controlled by proteins facilitate explicit mineral formation with intricate supramolecular architectures in nature. Mimicking natural proteins, engineered short polypeptides, aka GEPIs, are ubiquitous molecular tools in addressable functionalization of solid interfaces. Simplicity of peptide sequences and functional domains offer latent means for interrogating intermolecular forces towards tailored molecular recognition and signal transduction. Using biocombinatorially selected and rationally designed peptides, our team has been demonstrating organized biomolecular architectures as potent utility in nano-electronics/photonics and molecular-medicine. Starting from biological fundamentals, this talk will present practical utility of GEPIs in vast array of implementations encompassing many of the developments in hybrid materials fabrication, all under biologically viable conditions of water, pH7, RT, and atmospheric conditions, during the last 2 decades. Supported by NSF-DMREF and Amazon-Catalyst Programs.
Proceedings Inclusion? Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)


Bioconjugated Nanoparticle Imaging Probes for Molecular Imaging with Computed Tomography
Biofilm Formation Behavior on Polymer Brush Surfaces by E. Coli and S. Epidermidis
Biomolecular Design of Soft Interfaces for Technology and Medicine
Chemically Functionalised Graphene FET with Double Conductance Minima for the Label-free Sensing of Exosomes
Connecting Biology and Electronics with Protons: From Ion Channels to Cells
Discovery of Biomaterials by Simulation and Experiment: Catalysts, Composites, and Therapeutics
Effects of Hydration and Mineralization on the Mechanical Behavior of Collagen Fibrils
Investigating the Interaction of Amyloidogenic Proteins with Inorganic Surfaces, Nanoparticles and Biomolecules by Atomistic Simulations
Modeling the Mechanics of Cancer Cells on Tissue Engineering Substrates
Nanoclay Based Tissue Engineering Scaffolds for Mimicking Biointerfaces in Mesenchymal to Epithelial Transision of Prostate and Breast Cancer Metastasis to Bone
Nanoscale Structure and Properties of Biomaterials
New Antimicrobial Peptides Generated through Genetic Algorithm Approach Using Chemical Property Based Cross-over
Oligopeptides and Recombinamers at Surfaces and Interfaces to Address Oral Infections
Revealing the Full Hierarchical Structure of Spider Silks across All Length Scales
Revealing the Multi-functional Surface and Material Property of Venus Flytrap (Dionaea Muscipula)
Single Molecular Imaging of Fluorescent-tagged Peptides Diffusing on a Surface of Boron Nitride
Surface Modification of Ti6Al4V to Confer Antibacterial Properties against Listeria Monocytogenes
Synthesis and Characterization of Superomniphobic Surfaces Inspired by Springtails
Transmission Synchrotron X-ray Tomography and Nano-indentation Measurements for the Investigation of the Teeth Microstructure of Dinosaurs
Use of Nanostructured Diamond in Medical Device Applications

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