| About this Abstract |
| Meeting |
Materials Science & Technology 2012
|
| Symposium
|
Surface Properties of Biomaterials III
|
| Presentation Title |
Aspects of Hydrodynamic Shear Regulating Platelet Adhesion to Extracellular Matrix Components |
| Author(s) |
Sriram Neelamegham |
| On-Site Speaker (Planned) |
Sriram Neelamegham |
| Abstract Scope |
Platelet adhesion to substrates bearing collagen and other extra-cellular matrix components is a key regulator of thrombosis in both the injured vessel wall and in biomaterial implants. The process of platelet adhesion under these conditions is regulated not only by the activation state of blood platelets, but also by hydrodynamic shear which is prevalent in the vasculature and soluble blood coagulation proteins like the von Willebrand Factor (VWF). This paper will discuss some of our recent work on the basic mechanisms regulating platelet adhesion and their interaction with collagen under fluid shear. Specifically, I will discuss how fluid shear regulates VWF size in circulation by controlling both VWF self-association and its mechanoenzymatic proteolysis by ADAMTS13. The talk will also present a discussion of domain level changes in VWF structure that regulate platelet-biomaterial interaction. |
| Proceedings Inclusion? |
Planned: None Selected |