Nano metallic multilayers (NMM) can be utilized as model systems to investigate nano-scale phenomena due to the many sample characteristics that can be tuned in a controllable manner. In this study, sputtered multilayer and monolithic samples were used to investigate the predicted high-temperature nanograin stability of the Hf-Ti system. Recently, modeling and experiments have identified several material systems as having thermodynamically stable nanograins at elevated temperatures. At specific compositions, the calculated interfacial energies predict that some systems, such as Hf-Ti, Mo-Au, Nb-Cu, and Ta-Cu, will have stable nanograins, while others, such as Co-Cu, Cr-Cu, and Ni-Cu, will not have stable nanograins. In order to examine the feasibility of using nano metallic multilayers as a route to produce stable nanograined structures, several of the modeled systems were selected for multilayer fabrication. This talk will discuss the microstructural evolution of these multilayer samples after heat treatment.