About this Abstract |
Meeting |
MS&T22: Materials Science & Technology
|
Symposium
|
Society for Biomaterials: Biomaterial Applications
|
Presentation Title |
Silanized Titanium for Delivery of Hydrophobic Therapeutic in Aqueous Environment |
Author(s) |
Zoe Harrison, Joshua R. Bush, Felio Perez, Joel D Bumgardner, Tomoko Fujiwara, Daniel L Baker, Jessica Amber Jennings |
On-Site Speaker (Planned) |
Joshua R. Bush |
Abstract Scope |
Drug eluting coatings can prevent biofilm on titanium implants, but many therapeutics are hydrophobic and may not be retained when coated onto a hydrophilic metal surface. Titanium coupons were silanized with n- decyltrimeth-oxysilane (DTMS) to provide a hydrophobic environment to hold hydrophobic therapeutic molecules, such as signaling factor 2-Heptylcyclopropane-1-carboxylic acid (2CP), for controlled delivery. FTIR analysis of the titanium surface indicated the presence of the silane layer and showed distinct difference with a drop-coated layer of the 2CP signaling molecule. Contact angle analysis of the silanized surface shows the high contact angle of a hydrophobic surface. However, when 2CP coats the surface, the contact angle reduces to near zero. This likely shows that the hydrophobic tail of the 2CP molecule is interacting with the carbon chains at the surface, leaving the hydrophilic, acid end of the molecule facing the aqueous environment, aiding in therapeutic delivery to the surrounding tissue. |