|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Biodegradable Materials for Medical Applications
||Osteosynthesis in an Osteoporotic Rat Model Using Magnesium-based Pins
||Nicole Gruen, Daniela Hirzberger, Johannes Eichler, Nicholas Donohue, Annelie-Martina Weinberg
|On-Site Speaker (Planned)
Osteopososis is an economic and medical burden worldwide. Functionalized implants which could support fracture healing is a vision and biodegradable materials constitute a promising approach to treat osteoporotic fractures. Twelve-month old Spraque Dawley rats underwent bilateral ovariectomy to induce osteoporosis or sham-operation. Twelve weeks after ovariectomy, magnesium-based implants (with calcium and zinc) were transcortically implanted into the proximal tibiae. Micro-computed tomography was performed 4, 8 and 12 weeks after ovariectomy to observe osteoporosis progression and 2, 6, 15 and 18 weeks after magnesium implantation. Here we demonstrated osteoporosis progression after bilateral ovaiectomy. Moreover, ÁCT scans showed new bone development and callus formation 2 weeks after Mg implantation. Gas formation associated with implant corrosion did not disturb adequate osseointegration in this model. We therefore suggest better osseointegration and bone formation with Mg-based implants compared to conventional alloys. Moreover, Mg-based implants constitute a promising tool to treat osteoporotic fractures.
||Planned: Supplemental Proceedings volume