The development of functional nanomaterials with multi-interrogation modalities opens up new avenues for creating multi-purpose technologies for many applications. Multifunctional nanoparticles take advantage of the physicochemical properties of two or more materials to create a new multifunctional composite nanostructure. The “ideal” nanoparticle would combine multiple detection modalities (magnetic, plasmonic, elastic or inelastic light scattering, fluorescence, storage, tracking, delivery), be stable under biological/industrial conditions, could be easily functionalized, environmentally friendly, and could be prepared in large quantities. Noble metal nanoparticles, particularly gold and silver, have exciting physical and chemical properties that are entirely different from the bulk and meet many of these characteristics. By combining these metallic nanomaterials with either magnetic (Fe2O3) or photocatalytic (TiO2) materials one could create tunable multifunctional nanostructures with multi interrogation-capabilities, e.g. plasmonic, magnetic, catalytic functionalities. The objective of this talk is to discuss our recent synthesis and characterization techniques used to create different size, shape, composition and morphology multifunctional nanoparticles and their corresponding applications.