Ordered metallic crystalline lattices are often considerably harder and stronger than typical disordered solid solutions due to their specific atomic structure and chemical bonding nature. Generally, such intermetallic compounds are brittle or exhibit low fracture toughness. However, some precious metal-rare earth binary intermetallics with B2 structure have displayed considerable ductility at room temperature, due to their cubic lattice and chemical bonding attributes. This work explores the effects of lattice strain and bond enthalpy with multiple elemental substitutions for the precious metal [Ag, Au, Cu, Pd, Ni] and rare earth [Dy, Gd, La, Sc, Y] sites for the B2 stoichiometry. Quaternary/senary alloys were produced by arc melting and solution treating. Results show that most elemental combinations produce a multicomponent B2 structure and that hardness and ductility are related to the miscibility of the elemental couples and the degree of lattice distortion imposed by the elemental combinations on the cubic cell.