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Meeting 2016 TMS Annual Meeting & Exhibition
Symposium Magnesium-based Biodegradable Implants
Presentation Title Standardized Guidance for the Preclinical Evaluation of Absorbable Metal Implants
Author(s) Byron K. Hayes
On-Site Speaker (Planned) Byron K. Hayes
Abstract Scope Absorbable metallic implants constitute a technology in its infancy, with new cardiovascular and orthopedic devices (principally magnesium based) only now entering the marketplace. The technology brings a fundamental shift in the paradigm of corrosion, moving from a historical focus on its complete prevention to one of managing the entire corrosion process, including the generated degradation products. Since an implant needs to perform its structural function and also remain compatible with the body’s physiology, complete implant corrosion brings a multitude of new questions (and potential understandings). Since any medical implant needs to demonstrate a predictable level of safety, identification of appropriate standards for evaluating an implant that intentionally corrodes is needed. A collaborative effort between ASTM and ISO has been initiated to develop standardized guidance for researchers, regulators, and product developers to appropriately evaluate the composition, degradation, and biocompatibility of these new materials and their relatively complex in vivo degradation processes.
Proceedings Inclusion? Planned: A combination print-CD volume


Absorbable Filament Technologies: Wire-drawing to Enable Next-generation Medical Devices
Appropriate Corrosion-FatigueTesting of Magnesium Alloys for Temporary Bio-implant Applications
Computer Simulation of the Mechanical Behaviour of Implanted Biodegradable Stents in a Remodelling Artery
Degradation of MgF2-coated and Uncoated MgNd2 Specimens in Contact with Nasal Mucosa
Fabrication, Testing and Performance of Rare Earth-containing Magnesium Biodegradable Metals
In Vitro Corrosion and Cytocompatibility Properties of Mg-2Gd-X(Ag, Ca) Alloys
Influence of Precipitation Hardening in Mg-Y-Nd on Mechanical and Corrosion Properties
Magnesium-based Compression Screws
Magnesium Powder Injection Molding (MIM) of Orthopedic Implants for Biomedical Applications
Manufacturing of Osteosynthesis Systems Made of Magnesium Alloy AZ91
Monitoring Biodegradation of Magnesium Implants with Sensors
Plasma Surface Modification of Magnesium-Based and Related Biomaterials
Standardized Guidance for the Preclinical Evaluation of Absorbable Metal Implants
The Industrial Challenges of Manufacturing Bioabsorbable Magnesium
Understanding Corrosion-assisted Cracking of Magnesium Alloys for Bioimplant Applications

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