In current work, serration characteristics were studied on high-entropy alloys (HEAs) in a temperature range from 298 K to 1,073 K and in a strain-rate range from 2 x 10-3/s to 5 x 10-5/s during compression experiments. The serrated flow was most strongly observed from 673 K to 873 K with strain rates of 2 x 10-4 /s and 5 x 10-5 /s. The effects of phase transformation, twinning, and interactions between solute atoms and dislocations on the serrated flow were investigated, using the transmission electron microscopy (TEM) and atom-probe tomography (APT) method. The statistical distributions of stress-drop amplitudes, serration types, and critical strains during tension, compression, and creep experiments were studied, which facilitated the mechanistic study of serrated flows in HEAs. The serrated flow behavior is explained qualitatively on the basis of the mean-field model, developed by Dahmen, aiming to provide in-depth understanding for the plastic deformation of HEAs.