| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biomaterial Applications
|
| Presentation Title |
Hybrid 3D Bioprinting of Tissue Engineering Scaffolds with Dual Delivery Capability for Anticancer Drugs |
| Author(s) |
Jiahui Lai, Man Hang Mathew Wong, Min Wang |
| On-Site Speaker (Planned) |
Min Wang |
| Abstract Scope |
Tumor resection is a major cancer treatment method but can result in tissue defects that greatly lower patients’ quality of life. Tissue regeneration and killing of possible residual tumor cells are critical for these patients. 3D bioprinting enables fabrication of superior cell-scaffold constructs for tissue regeneration. Anticancer drugs are often used together to provide effective chemotherapy. 3D printed scaffolds incorporated with anticancer drugs can kill residual tumor cells while regenerating body tissues. In this study, dual-drug loaded and cell-laden scaffolds were fabricated through hybrid 3D bioprinting of a synthetic polymer ink and a natural polymer bioink and were subsequently studied. The synthetic ink contained nanoclay, PEGDA and doxorubicin hydrochloride (DOX); the natural bioink contained alginate, CaCl2, 5-fluorouracil (5-Fu) and mesenchymal stem cells (rBMSCs). These scaffolds exhibited favorable cell behavior for tissue regeneration together with controlled dual release of DOX and 5-Fu, showing high potential for treating cancer patients after surgery. |