Plastics deformation of materials are usually related to the structural flow units in the materials. This units can be dislocations, twins, grain boundaries, for crystalline materials; and free volume, shear transformation zone (STZ), liquid like regions for amorphous materials. While for the high entropy alloys, which are usually body centered cubic (BCC) or face centered cubic (FCC) solid solution disordered phases, the flow units will be complex at different loading conditions, e.g., at different strain rates and at different temperatures. The solute atoms will segregate at the dislocations and will interact with the dislocation when the high entropy alloys are deformed and the dislocations are moveing. The paper will discuss this issue with a model of a BCC and FCC high entropy alloys. The serration behaviors will be monitored for the stress and strain curves.