|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Biodegradable Materials for Medical Applications
||Osteosynthesis in a Growing Ovine Model using Bioresorbable Rare-earth-free Magnesium Screws
||Johannes Eichler, Patrick Holweg, Leopold Berger, Martina Cihova, Nicholas Donohue, Nicole Grün, Jörg Löffler, Annelie Weinberg
|On-Site Speaker (Planned)
Osteosynthesis of bone fragments using titanium (Ti) screws may result in loosening, inflammation and subsequent removal operations. Magnesium (Mg) screws degrade after implantation, are mechanically similar to bone and could support healing. Previously, rare earth (RE) elements were added to control Mg degradation, although long-term effects are unknown.
Using CT imaging, we evaluated fracture healing around a RE-free, Mg-zinc-calcium alloy (ZX00, Mg-0.45Zn-0.45Ca) screw in an in vivo growing sheep tibia osteotomy model.
Callus formation was observed after 2 weeks, was stable after 6 and progressed to resorption after 12 weeks, without qualitative differences compared to Ti implants. The interface between bone and Mg screws showed increased bone mass.
Mg screws exhibited homogenous degradation and moderate hydrogen formation, which did not disturb surrounding tissue or healing. Fracture stabilization and healing were comparable to Ti osteosynthesis. The absence of RE in ZX00 make it especially promising for treating children.
||Planned: Supplemental Proceedings volume