|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||Iron/Iron Oxide Core/Shell Nanoparticles for Magnetic Hyperthermia Treatment
||I. Baker, Katsiaryna Kekalo
|On-Site Speaker (Planned)
Magnetic nanoparticles accumulated in tumors either by direct injection or by using tumor-targeted antibodies introduced though the vasculature and subjected to an alternating magnetic field (AMF) are being pursued for cancer therapy. The localized heating of the tumor, via nanoparticle heating from the AMF, to 44-45oC for sufficient time causes apoptosis of the tumor cells. This presentation will discuss the preparation of novel iron/iron oxide core/shell nanoparticles for this purpose using a microemulsion method and their characterization using scanning electron microscopy, transmission electron microscopy and vibrating sample magnetometry. The particles are produced with a cetyl trimethyl ammonium bromide coating, which is subsequently replaced with either a phospholipid or dextran coating. The effects of these coatings on both the nanoparticles’ magnetic properties and heating behavior in an alternating magnetic field will be discussed. A comparison with the behavior of dextran-coated iron oxide nanoparticles will be presented.
Support: NIH grant 1U54CA151662-01.