| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biomaterial Applications
|
| Presentation Title |
Combinatorial Approaches to Blood Contacting Materials |
| Author(s) |
Christopher Siedlecki, Lichong Xu |
| On-Site Speaker (Planned) |
Christopher Siedlecki |
| Abstract Scope |
Infection and thrombosis remain significant problems for the successful use of implanted medical devices. Proteins, platelets and bacteria all interact with surfaces, the latter two indirectly via interactions with an adsorbed protein layer on the device surface. We have developed a strategy for addressing these problems that utilizes a combination of sub-micron surface textures along with nitric oxide release from small molecules physically trapped within a variety of biomedical polymer materials. Benchtop experiments show reductions in the numbers of bacteria and platelets attached to the surface, in the initiation of the coagulation cascade as well as significant reductions in the development of mature biofilms on the material surface. In this presentation, we will discuss the strategy, present results showing affects of this combinatorial approach on both thrombus formation and infection, and provide insight into the molecular mechanisms behind this approach. |