|About this Abstract
||2016 TMS Annual Meeting & Exhibition
||Biological Materials Science Symposium
||E-3: Biological Response of Interconnected Ti-6Al-4V Foam Constructs for Biomedical Implants: A Vascularization Issue
||Victor Correa, Kristine Garza, Lawrence Murr
|On-Site Speaker (Planned)
The main issue in the field of tissue engineering resides in the vascularization of implanted structures. By intercalation of hypoxia-inducible factor-2α (Hif-2α) and Vascular Endothelial Growth Factor (VEGF) promoters in an aqueous matrix, successful vascularization can be achieved. In this study, an interconnected foam structure of Ti-6Al-4V was micro-fabricated by Electron Beam Melting (EBM) techniques. Foams of the same density were fabricated containing vascular templates of 0.5mm in diameter. The structure in question has a density of 1.77g/cm3 with 60% porosity and a modulus of 18GPa. The seeding efficiency of these foams is of 58%. Biological testing such as total protein content and SEM imaging reveal that MC3T3-E1 pre-osteoblast cells undergo proliferation and also attach efficiently to the foam. Further investigation is ongoing to evaluate the potential for vascularization of Human Umbilical Vascular Endothelial Cells (HUVECs) in order to develop living implants.
||Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)