|About this Abstract
||2016 TMS Annual Meeting & Exhibition
||Bio Nano Interfaces and Engineering Applications
||Self-reinforced Fibro-porous 3D Tubes for Vascular Graft Applications
||Vinoy Thomas, Paloma F Coelho, Siddhartha Patel, Andrew T Wood
|On-Site Speaker (Planned)
Synthetic graft made of ePTFE and polyethylene terephthalate (PET) have issues of low patency (20% for 2 years) due to mechanical mismatch, thrombosis and intimal hyperplasia. In this study, new self-reinforced 3D tubes with spirally reinforced nanofibers of PET and elastomeric polyurethane (PU) blends have fabricated by depositing fibers onto a rotating mandrel (6 mm) with an inserted spring capable of vibration-free rotation at high speeds, which produced asymmetric fiber distribution with reinforcing-spiral formation. The structural and morphological property evaluation by FT-IR, differential scanning calorimetry (DSC) and scanning electron microscope (SEM) were carried out in addition to porosity and water absorption characteristics. Mechanical property by tensile test showed an improvement of the grafts’ strength which could be further tuned by varying the blend composition. Addition of PU improved the flexibility, strength, and kink resistance in spirally reinforced vascular grafts for potential application as hemodialysis access graft and peripheral arterial graft.
||Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)