|About this Abstract
||2016 TMS Annual Meeting & Exhibition
||Recent Developments in Biological, Structural and Functional Thin Films and Coatings
||Surface Functionalization of Titanium Substrates for Improving Osteointegration
||Quang Van Le, Mathilde Giraudel, Geneviève Pourroy, Caroline Fischer, Koenig Géraldine, Leandro Jacomine, Jacques Faerber, Fabienne Perrin-Schmitt, Adele Carradò
|On-Site Speaker (Planned)
We present a designed multilayer system using ‘chimie douce’ to bond calcium phosphate (CaP) to titanium (Ti) and we demonstrate the bioactivity of specimens obtained through this technique. The implant surface was modified by mechanical, chemical and heat treatments, then a Ca-P layer was deposited onto the metal surface by sol-gel route.
Scanning electron microscopy of superficial layers showed micro-structure with pore sizes ranging from 0.1 to 1 µm. Scratch tests demonstrated the strength of the bonding to the Ti support, and no delamination occurred with a maximal load of 100 mN. Finally, biological evaluations such as cell morphology and density as well as cell viability were performed. MC3T3-E1 cells have shown that bioactive CaP coated surfaces increase both growth rate and differentiation of preosteoblast to osteoblast. CaP coated supports increased the cell growth rate in culture, and favored a 3D cellular network organization.
||Planned: A print-only volume