|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Biological Materials Science
||H-19: Aligned Carbon Nanotubes Reinforced Electrospun Polymeric Scaffold for Peripheral Nerve Repair
||Pallavi Gupta, Murali Kumaraswamy, Partha Roy, Debrupa Lahiri
|On-Site Speaker (Planned)
Carbon nanotubes (CNTs), due to their unique electrical properties, have potential to the repair the neural injuries. This study demonstrates the in vitro and in vivo efficacy of CNT-reinforced aligned polymer electrospun nanofibrous scaffold in the repair and regeneration of transected nerve. The in vitro study confirmed the HT-22 hippocampal neurites orientation in the direction along the aligned CNT–polymer scaffold and also that the CNT alignment increases the maximal neurite length significantly. The electrospun scaffolds were also characterized for their tensile strength and electrical conductivity. Four weeks after implantation of an aligned CNT–polymer nerve conduit into the 15 mm gap of a transected rat sciatic nerve, show that the scaffold had supported robust neural regeneration across the gap. Thus, the results strongly support the potential use of aligned CNT-reinforced polymer nanofibrous scaffolds as the interface between the nerve conduit and peripheral neural tissues.
||Planned: Supplemental Proceedings volume