Directed Energy Deposition (DED) processes involve focused thermal energy used to fuse materials by melting as they are being deposited. DED processes could include wire feed and powder feed processes, using lasers or electron beams as the energy source. In addition to rapid prototyping and manufacturing, DED processes are suitable for feature addition and repair, thus the qualification of DED processes is of great interest. Extensive empirical testing to fully qualify a material often requires thousands of individual tests, costing millions and many years to complete. A minor change in the process requires complete requalification. This presentation outlines a model-based qualification framework, in which a material’s or process’ performance is demonstrated in a computer model and verified with minimal testing, for DED processes. This requires validated high-fidelity process models and in-situ monitoring and control sensors. The relationship between process models, critical process parameters, in-situ-sensors, and process qualification will be addressed.