|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||2018 Symposium on Functional Nanomaterials: Discovery and Integration of Nanomaterials
||Mechanism of Antibacterial Activity of ZnO and Cu-ZnO Nanostructures Against S.aureus
||Shaila Thakur, Sudarsan Neogi
|On-Site Speaker (Planned)
In this study, the antibacterial activity of chemically synthesized ZnO and Cu-ZnO heterostructures has been investigated against S.aureus. The minimum inhibitory concentration (MIC) of nanoparticles against S.aureus was evaluated by microdilution method. A time dependent cell viability of S.aureus was investigated for duration of 12 h and 350 microgram/ml nanoparticle concentration. The antibacterial activity was further substantiated with the help of Field Emission Scanning Electron Microscope (FESEM) and Transmission Electron Microscope (TEM). Membrane damage and release of cellular components in nanoparticle treated bacteria was evident from the images. The changes in bond vibration modes on exposure to nanoparticles were studied using Fourier transform infrared spectroscopy. As compared to untreated bacterial cells, FTIR of nanoparticle treated cells showed the breaking of amine bonds and subsequent distortion of protein structure. The band for amide II was absent in the spectra of S.aureus treated with nanoparticles.
||Planned: Supplemental Proceedings volume