Lithium-sulfur cells have experienced considerable attention recently, given their order of magnitude higher theoretical capacity compared to Li-ion cells. The active material, sulfur, undergoes changes in physical and chemical states as the cell operation proceeds. For example, during discharge, impregnated solid sulfur dissolves in the electrolyte, successively reduces to lower order sulfides and eventually precipitates as Li2S. Commensurate temporal variations in electrode pore network are also experienced, which manifest as volumetric strain for the solid skeleton. This bulk strain causes stress distribution in the electrode structure and subsequently leads to electrolyte flow. In addition to this stress cycling being detrimental to structural rigidity, electrolyte flow carries the active species away from reaction sites, thus negatively influencing cell performance. The present study models this reaction induced stress and stress induced transport effects, and correlates them with cathode microstructural descriptors. The investigation suggests possible avenues for electrode microstructural tuning of stress accommodation.