|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||Human Fetal Liver Cell Culturing in Porous Hydroxyapatite/Hyaluronic Acid Composites
||Anthony Finoli, Patrick Over, Eva Schmelzer, Jorg Gerlach, Ian Nettleship
|On-Site Speaker (Planned)
Each year 30,000 people die from chronic liver disease in the United States. Transplantation is generally the only cure but available organs are far outnumbered by the patients need. To create transplantable tissue in-vitro, a three-dimensional scaffold must be used to create a protective environment for tissue to form. This project aims to culture primary human fetal liver cells in a bioactive composite consisting of a hydroxyapatite foam and a hyaluronic acid hydrogel matrix embedded with human fetal liver cells. The processing of this composite will be presented. Also the results of long term cell culturing experiments will be presented which showed a ten-fold increase in albumin secretion, an indicator of mature liver cell activity, over current culture methods.