About this Abstract |
Meeting |
MS&T22: Materials Science & Technology
|
Symposium
|
Society for Biomaterials: Biomaterial Applications
|
Presentation Title |
Novel Biodegradable Porous Magnesium Alloy Scaffolds for Critical Sized Calvarial Bone Defect Reconstruction |
Author(s) |
Prashant Nagesh Kumta, Abhijit Roy, Mubin Ali Aral, Matthew Criado, John Ohodnicki, Fatih Zor, Vijay Gorantla, Alejandro Almarza, MaCalus Hogan |
On-Site Speaker (Planned) |
Prashant Nagesh Kumta |
Abstract Scope |
Bone reconstruction of large area critical-sized calvarial bone defects in the craniomaxillofacial (CMF) region is clinically challenging. Resorbable and non-resorbable materials used for calvarial grafts often exhibit bone resorption, infections, inflammation and suboptimal osseointegration. Biodegradable magnesium (Mg) and Mg alloys are promising for CMF applications. However, there are no studies demonstrating the local and systemic toxicity of these alloys in a critical sized craniofacial model, particularly, when the implant is in physical contact with the periosteum. A new biodegradable Mg alloy based cranial bone graft (MgCBG) is presented demonstrating in vivo safety and efficacy as well as biomechanical stability when placed in the rat calvarial critical sized bone defect model. Results indicate that the developed MgCBG slowly degrades over 26 weeks forming new bone devoid of any local/systemic toxicities. The MgCBG also exhibit better bone regeneration and osseointegration compared to surgical grade poly-ether-ether ketone-based graft. |