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Meeting MS&T22: Materials Science & Technology
Symposium Society for Biomaterials: Biomaterial Applications
Presentation Title Novel Biodegradable Porous Magnesium Alloy Scaffolds for Critical Sized Calvarial Bone Defect Reconstruction
Author(s) Prashant Nagesh Kumta, Abhijit Roy, Mubin Ali Aral, Matthew Criado, John Ohodnicki, Fatih Zor, Vijay Gorantla, Alejandro Almarza, MaCalus Hogan
On-Site Speaker (Planned) Prashant Nagesh Kumta
Abstract Scope Bone reconstruction of large area critical-sized calvarial bone defects in the craniomaxillofacial (CMF) region is clinically challenging. Resorbable and non-resorbable materials used for calvarial grafts often exhibit bone resorption, infections, inflammation and suboptimal osseointegration. Biodegradable magnesium (Mg) and Mg alloys are promising for CMF applications. However, there are no studies demonstrating the local and systemic toxicity of these alloys in a critical sized craniofacial model, particularly, when the implant is in physical contact with the periosteum. A new biodegradable Mg alloy based cranial bone graft (MgCBG) is presented demonstrating in vivo safety and efficacy as well as biomechanical stability when placed in the rat calvarial critical sized bone defect model. Results indicate that the developed MgCBG slowly degrades over 26 weeks forming new bone devoid of any local/systemic toxicities. The MgCBG also exhibit better bone regeneration and osseointegration compared to surgical grade poly-ether-ether ketone-based graft.

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Additive Manufacturing and Characterization of Stimuli-Responsive Biomaterials for Cardiovascular Stents
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Antimicrobial Biomaterials Target Intracellular Infection
Bioactive Glass and Its Role in Healing
Bioactive Polyelectrolyte Layer by Layer Assembled Corrosion Resistant Coatings on Surface Treated MgAZ31 Alloys
Biodegradable Ceramic Coating on Lithium-Aluminum-Zinc (LAZ) and Lithium- Zinc (LZ) Magnesium Alloys Using Micro-arc Oxidation
Biodegradable Magnesium Fixation Wires for Bone Healing
Combinatorial Approaches to Blood Contacting Materials
Development of a Microfluidic Blood-Vessel-on-Chip Model
Development of Natural Polymer-based Hydrogels for Corneal Tissue Engineering Applications
Development of Tissue-Specific, Perfusable Vasculature in Microphysiological Systems
Electrospraying Chitosan on Co-electrospun PCL/PVA Composite with Mesoporous Silica Particles to Release Curcumin for Skin Tissue Engineering Application
Exploring Single Electrospun PLGA Fiber Mechanics and Fiber Mat Applications in Cardiac Bioengineering
Exploring the Potential of Strontium Substituted Amorphous Calcium Phosphate and Dicalcium Phosphate Dihydrate Based Hydroxyapatite Forming Bone Cement
Harnessing Biological Functions in Dental Materials
Harnessing Perfluorocarbons to Enhance Oxygenation in Engineered Tissues
Hybrid 3D Bioprinting of Tissue Engineering Scaffolds with Dual Delivery Capability for Anticancer Drugs
Hydroxyapatite Loaded with 2-heptylcyclopropane-1-carboxylic Acid Inhibits S. Aureus Biofilm Formation
In Vitro Biochemical Analysis of Bioactive Glass Ionomer Cement (45S5) with Citric Acid as Setting Modifier
Magnesium-Based Nanocomposites for Bone Fracture Repair
Novel Biodegradable Porous Magnesium Alloy Scaffolds for Critical Sized Calvarial Bone Defect Reconstruction
Plant Polymer for Climate and Health Management
Platinum Wire-based Aptasensors Exploiting Self-assembled Monolayer (SAM) Components for Cardiac Biomarker Detection
Silanized Titanium for Delivery of Hydrophobic Therapeutic in Aqueous Environment
Silver Doped Titanium Oxide Layers for Improved Photocatalytic Activity and Potential Antibacterial Properties of Titanium Implants
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