|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||Degradation of Tailored Amorphous Multi Porous (TAMP) Bioscaffolds
||Di Zhang, Shojie Wang, Leena Hupa, Himanshu Jain
|On-Site Speaker (Planned)
In future, bioscaffolds are expected to help regenerate a diseased or missing human tissue via tissue engineering. A key material requirement for the performance of bioscaffold is that its degradation rate should match the growth rate of the tissue it is supposed to help regenerate. To tune the degradation rate of bioscaffolds for hard tissue replacement, tailored amorphous multi-porous structures (TAMPS) have been developed with appropriate pore size distribution that controls overall surface area. In this paper we will focus on the correlation between degradation rate and pore size distribution that may range from a few nm to hundreds of microns. The overall performance is a complex effect of leaching, dissolution and precipitation, all of which can be strongly pore size dependent. To illustrate the main issues, initial results will be presented on the degradation of 70SiO2•30CaO nano-macro TAMPs in simulated body fluid under static and quasi-dynamic in vitro conditions.