The inclusion removal in steelmaking process has received much attention due to the increasing demand for the high steel cleanliness over decade. The inclusion removal mechanism in the ladle metallurgical furnace is very complex, which includes fluid flow, inclusion collision and coalescence, inclusion floatation, adhesion to the ladle wall and gas bubbles, slag eye formation at the liquid surface, etc. A CFD model was developed to investigate the collision, nucleation, growth and removal of inclusions in bottom gas-stirred ladles. The results show that the top slag capture is the major mechanism for inclusion removal. They also indicate that the bigger inclusions can be removed more easily than the smaller ones. The porous plug configuration and bubble size have important effects on the inclusion removal behavior. The eccentric bottom blowing is more efficient for inclusion removal than the centric bottom blowing. The smaller bubbles provide higher removal amount of inclusions.