Microstructure, phase stability, tensile properties, creep and oxidation resistance of CoCrFeNi-based multi-principal element alloys were explored to understand alloying effects and to assess advantages against Ni-based superalloys. Alloys containing combinations of γ’-Ni3(Al,Ti) formers (Al and/or Ti) and a refractory element (Nb, Mo or Ta) to form additional strengthening precipitates were prepared and hot rolled to a sheet form, followed by solution and precipitation hardening treatments. Tensile and creep tests at 760 and 871°C showed presence of the γ’ precipitates is the primary contributor. Laves and σ phase precipitates in alloys containing Nb and Mo, respectively, are useful in suppressing formation and coalescence of cavities along grain boundaries during creep deformation. Identifying alloy compositions that raise the γ’ solvus without lowering the solidus while forming stable, fine grain boundary precipitates is the key for enhancing high temperature mechanical properties. The measured properties will be discussed in comparison with conventional wrought superalloys.