| About this Abstract |
| Meeting |
MS&T21: Materials Science & Technology
|
| Symposium
|
Nanotechnology for Energy, Environment, Electronics, Healthcare and Industry
|
| Presentation Title |
Dissolution of Atherosclerosis Plaque in Human Coronary Artery Induced by Nanobubbles |
| Author(s) |
Ao Li, James C. Earthman |
| On-Site Speaker (Planned) |
Ao Li |
| Abstract Scope |
Atherosclerosis causes approximately 30% of global mortalities each year. Invasive treatments for atherosclerosis, such as coronary stent placement, have been widely used. However, they are generally exceptionally expensive and may lead to detrimental side effects. Bulk nanobubbles (NBs) were observed to capture nanoparticles and form clusters in various liquids. We have proposed that clustering of embryo nanoparticles can induce the dissolution of bulk forms of the same compound which is in the nanoparticles. This phenomenon raises the possibility for applying NBs for treating calcified plaque to dissolve the calcium compounds within the plaque. In the present study, ex vivo human coronary artery samples with atherosclerosis plaque were exposed to NBs in circulating Ringer’s solution. Within a 4 hour exposure, the volume of the plaque decreased by 18% to 40% in the presence of NBs while much smaller reductions were observed in untreated Ringer’s solution control experiments. |