|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Pan American Materials Congress: Advanced Biomaterials
||In Vivo Study on New Coronary Stents Made of Nickel-free High-nitrogen Stainless Steel
||Qingchuan Wang, Shanshan Chen, Hui Yang, Bingchun Zhang, Ke Yang
|On-Site Speaker (Planned)
This study was focused on the preclinical in vivo study of a novel kind of coronary stents made of high-nitrogen nickel-free stainless steel (HNNFSS). Both bio-safety and effectiveness of HNNFSS stents with and without drug-eluting coating were compared with commercial available stents after 14, 28 and 90 days implantations in porcine coronary arteries, respectively. It was found that all the stents showed well expansion and sufficient radial force without significant elastic recoil. After 28 days implantation, the bare stents control group showed the most serious degree of intimal hyperplasia, and the experimental groups displayed mild inflammatory response and more intact internal elastic lamina. It is worth noting that the experimental bare stents had significant advantage over the control group after 90 days implantation (P<0.05). In conclusion, HNNFSS stents showed better biocompatibility, lower in-stent restenosis and obvious advantage on degree of intimal hyperplasia after long-term implantation.
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