In this research, the interaction of shear coupled grain boundary motion (SCGBM) in face-centered cubic metals with crack has been studied by using molecular dynamics simulations in simple bicrystal models. The influences of metal type, temperature, grain boundary structure, and crack geometry have been examined systematically. Three types of microstructural evolution have been identified, namely, crack healing, grain boundary decohesion, and sub-grain formation. The underlying atomistic mechanisms for each type of SCGBM-crack interaction, particularly grain boundary decohesion and crack healing, have been explored. It is found that crack healing can be enhanced by applying cyclic shear loading, which is accompanied by a structural transformation in the grain boundary by rearranging the basic structural units. The healed structure is stable and strong, which sheds some light for healing severely damaged polycrystalline materials.