About this Abstract |
Meeting |
2020 TMS Annual Meeting & Exhibition
|
Symposium
|
Advanced Real Time Imaging
|
Presentation Title |
Tunable Self Assembled Supramolecular Nanoprobes to Decipher Biomedical Events |
Author(s) |
Mathew Jaeschke, Sarah VanOosten, Philip Elrod, Esra Yuca, Candan Tamerler |
On-Site Speaker (Planned) |
Mathew Jaeschke |
Abstract Scope |
Controlled interactions at the biological-material interfaces have a vast amount of engineering and clinical applications that may lead to novel imaging, diagnostic, and therapeutic systems. Recently, we have explored combining multiple sensing and imaging modalities using metallic nanoparticles. Gold nanoparticles are among the common nanoparticles systems utilized in biomedical applications, ranging from targeted delivery of drugs to bioimaging and the monitoring of cells and tissues. By using gold-binding (AuBP) peptides conjugated to fluorescent proteins (GFP and DsRed) we can combine fluorescent imaging with metallic nanoparticles plasmonic responses. We investigated the wide range of applicability of the supramolecular nanoprobes under different protein and nanoparticles concentrations using localized surface plasmon resonance spectroscopy. The optimized bioactive nanoprobes were further investigated for their stability under physiological environments. We finally demonstrate their use as sensing modalities for monitoring inorganic ions for monitoring biomedical events. |
Proceedings Inclusion? |
Planned: |