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Meeting 2015 TMS Annual Meeting & Exhibition
Symposium Biological Materials Science Symposium
Presentation Title Biomimetic Interfaces for Peptide Mediated Antimicrobial Implant Coatings
Author(s) Deniz Yucesoy, Nicole Chin, Sarah VanOosten, Marketa Hnilova,
On-Site Speaker (Planned)
Abstract Scope Implant-associated infections or unsuitable implant-tissue interactions are still the major reason for failure of implants. There is an urgency to develop new preventative strategies at the implant site to extend implant lifetime and performance and, therefore, patient quality of life. Providing an active antimicrobial agent at the implant site without impairing the osseous-integration is among the most attractive preventive strategies. Here we demonstrate the use of designed chimeric peptide motifs as biological surface coatings to prevent bacterial growth. To achieve this, we first designed peptides that can specifically bind to implant surfaces. The specific peptide interactions were tested on cp. titanium, Ti-6Al-4V and zirconia based implants. We also designed peptides with antimicrobial properties using bioinformatics based tools. Finally, high similarity regions of the designed peptides are used to create chimeric peptides that accommodate both of the functions.Our results demonstrated the peptide coatings can potentially prevent infections at the implant interfaces.
Proceedings Inclusion? Planned: A print-only volume


4-D Imaging by X-ray Microtomography of the Failure Behaviour in Cuttlebone
A Nanomechanics Based Investigation into Interface Thermomechanics of Collagen and Chitin Based Biomaterials
Adhesion of Anodic Titanium Dioxide Coatings on Titanium Grades 5 Alloys
Adhesion of Blood Platelets in TiO2 Coatings
An Investigation into the Environment And Temperature Dependent Nanomechanical Properties of the Shallow Water Shrimp (PENAEUS SPP.) Exoskeleton
Atomistic Modeling of Self-Organisation in the Complex Structure
Behavior of Giant Vesicles in Acoustically-Excited Microchannels
Bio-inspired Synthesis of Ceramic Scaffolds by a Novel Sol-Gel/Freeze Casting Hybrid Method
Biochemical Characterisation of the Leaf of Morinda Lucida: Prospects for Environmentally-Friendly Steel-Rebar Corrosion-Protection in Aggressive Medium
Biocompatible Graphene Liquid Cells for High Resolution In-situ Imaging of Biological Matters
Bioinspired Design of Light-Harvesting J-Aggregate Nanotubes for Sensor Aapplications
Bioinspired Materials by Freeze Casting
Bioinspired Protection from the Armored Carapace of the Boxfish
Biomimetic Interfaces for Peptide Mediated Antimicrobial Implant Coatings
Biomimetic Surface Treatment of Titanium Alloys Associated Electrospinning
Bone Growth Behavior of Hydroxyapatite-Coated TiO2 Nanotubes
Bone Mimetic Nanoclay Testbed for Prostate Cancer
Characterization of the Degradation Behavior of Mg-Zr-Sr Alloys for Biomedical Applications
Cold Working Commercially Pure Ti for Dental Implants Applications
Combining Acoustic and Spectroscopic Measurement to Characterization Biological Entities
Creating Multi-Layered Collagen-Hydroxyapatite Composites Using Biomimetic Processing to Emulate Bone’s Mechanical Properties
Deformation and Fracture in Human Cortical Bone: Roles of Strain Rate, Irradiation Aging and Disease
Dentin Remineralization using Anionic Process-Directing Agents and Phosphate-Containing Small Molecules
Depth-Sensing Nanoindentation and Synchrotron Based XRF and XRD Investigation of Tungsten Exposed Bio-Monitoring Systems, Gastropod (Otala Lactea) Shells
Design and Optimization of Polymer Gels to Replicate Impact Energy Dissipation of Biological Tissues
Displacements of Bacterial Cells on Activated Photocatalytic Films
Enhanced Biocatalytic Property of Room Temperature Doped Cerium Oxide Nanoparticles
Experimental and Computational Characterization of Delamination Resistant Bio-Laminates
Experimental Characterization of Bone and Exoskeleton Fish Scale Structures
Extraordinary Tear Resistance of Skin
F24: The Investigation of Wear Resistance of Hydroxyapatite-chitosan Bio Composite Coating on Stainless Steel 316L
F25: Toughening Mechanisms in Nacre
F26: Microstructural Analysis of Aristotle’s Lantern in Sea Urchins
F27: Surface Magnetized Colloidal Particles Aligned by Magnetic Freeze Casting
F28: MoS2-Ceria Hybrid Nano-composite Based Electrochemical Biosensor
F29: Advances in the Understanding of the Effects of External Treatments on the Subcellular Structure and Composition of Plant Cell Walls
F30: Amperometric Detection of Hydrogen Peroxide and Dopamine by Ceria Nanoparticle-Functionalized Self-Assembled Monolayer Biosensor
F31: Regenerative Nanoporous Gold Biosensor in Harsh Biofouling Conditions
F32: Dynamic Modeling Approach to Follow Adsorption Kinetics of Engineered Proteins that Self-assembles Through Biomolecular Recognition
F33: Single Step Biofabrication of Self-Organized Hybrid Molecular Assemblies
F34: Towards Amperometric Sensors via Self Assembled Metal-specific Enzymes
F35: Easing the Fabrication of Bioinspired Composites Through the use of Clathrate Hydrates in Freeze Casting
F36: Microstructure, Mechanical Property of Porous Hydroxyapatite- TCP Biomaterial Consolidated by Rapid Sintering using Space Holder
F37: Silk Fibroin Bio-Polymer Integrated Nanostructures for Energy/Sensing Applications
F38: The Ganoid Scales of Atractosteus spatula: Potential for Bioinspired Flexible Armor
F39: Response of Osteoblast-Like Cells to Titanium Alloying Elements
F40: Comparisons of Apetite Deposition on the Surface of Titanium and Ti6Al4V Alloy Powders
In Vitro Studies of Surface Modified Highly Porous Ti6Al7Nb Alloys
Injectable Solids: Hydrogel Property and Nanostructure Control Through Peptide Design and Solution Assembly
Inspirations from Reptilian Eggshells for Novel Polymer-Based Composites
Interfacial Adhesion between Polymer and Osteoconductive Minerals
Investigation of Biological and Biomimetic Composites
Laser Induced Diffusion in Metallic Implants for Reduced Heating in MRI Environments
Layered Water in Bone as Key for Its Strength, Creep, Permeability, and Mechano-Sensitivity: A Unified Theoretical Approach Integrating Experimental Data Across the Disciplines
Magnetic Alignment of Ice Templated Ceramics
Magnetic Assembly of Bioinspired Composites Exhibiting Bouligand Structure
Magnetic Nanocomposites for Localized Hyperthermia Treatment of Breast Cancer
Molecular Basis of Disease: Experiments and Modeling in Osteogenesis Imperfecta (OI) of Human Bone
Multiscale Modeling of the Directed Self-Assembly Process for Bacteriophage Virus
Nano-Film Polymerization Process by Plasma-Deposited SnO2 for Biomaterial Applications: Study on Electrical Properties of Capacitor and Thin-Film Transistor
New Lessons from Nature by Revisiting Seashell’s Multiscale Architectures
Optical and Imaging Properties of Highly Luminescent Water Soluble Type II CdTe/CdSe Nanoparticles Synthesised via a Green Method
Phase Transforming Cellular Materials
Preliminary In-Vitro Study of Surface Alterations of Subcutaneous Venous Access Ports Exposed to Antineoplastic Drugs and Whole Blood
Prior Evaluation of Bioactive Coatings of Blood Contacting Applications
Production and Characterization of Magnesium Based Composites
Retaining Catalytic Mimetics of Cerium Oxide Nanoparticle Post Ion Interaction
Strain Rate Hardening: A Hidden but Critical Mechanism for Biological Composites?
Strength and Toughness of Nacre: Contributions of Minineral and Organic Components
Structural Analysis of the Woodpecker Tongue
Synthesis of Biomorphic TiO2 Using Leaf Vein as Template
Systematic Design of Bio-Inspired Materials: Exploring Synergies between Micro-Architecture and Interfaces for Simultaneous Stiffness, Strength and Toughness
Teleost Fish Scales Amongst the Toughest Collagenous Materials
Thermodynamic and Mechanical Properties of Bamboo in Nano-Scale
Time Dependent Behavior of Human Dentin
Toughening Mechanisms in Naturally-Occurring Helicoidal Composite Materials
Translation of Mg Alloy Properties to Stent Performance
Underwater Attachment and Functional Adaptations of River Loach

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