|About this Abstract
||2015 TMS Annual Meeting & Exhibition
||Biological Materials Science Symposium
||Biomimetic Interfaces for Peptide Mediated Antimicrobial Implant Coatings
||Deniz Yucesoy, Nicole Chin, Sarah VanOosten, Marketa Hnilova, Candan Tamerler
|On-Site Speaker (Planned)
Implant-associated infections or unsuitable implant-tissue interactions are still the major reason for failure of implants. There is an urgency to develop new preventative strategies at the implant site to extend implant lifetime and performance and, therefore, patient quality of life. Providing an active antimicrobial agent at the implant site without impairing the osseous-integration is among the most attractive preventive strategies. Here we demonstrate the use of designed chimeric peptide motifs as biological surface coatings to prevent bacterial growth. To achieve this, we first designed peptides that can specifically bind to implant surfaces. The specific peptide interactions were tested on cp. titanium, Ti-6Al-4V and zirconia based implants. We also designed peptides with antimicrobial properties using bioinformatics based tools. Finally, high similarity regions of the designed peptides are used to create chimeric peptides that accommodate both of the functions.Our results demonstrated the peptide coatings can potentially prevent infections at the implant interfaces.
||Planned: A print-only volume