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Meeting 2016 TMS Annual Meeting & Exhibition
Symposium Magnesium-based Biodegradable Implants
Presentation Title In Vitro Corrosion and Cytocompatibility Properties of Mg-2Gd-X(Ag, Ca) Alloys
Author(s) Yiyi Lu, Yuanding Huang, Frank Feyerabend, Regine Willumeit-Römer, Karl-Ulrich Kainer, Norbert Hort
On-Site Speaker (Planned) Yiyi Lu
Abstract Scope The effects of solution treatment (T4) on the in vitro corrosion properties were investigated for Mg-2Gd-xAg (x=1, 2 wt.%), Mg-2Gd-xCa (x=0.4, 0.8 wt.%) alloys. The cytocompatibility of pure Mg, Mg-2Gd, Mg-2Gd-2Ag and Mg-2Gd-0.8Ca alloy was studied as well. All alloys were prepared by permanent mould casting. T4 heat treatment was carried out at 510 °C for 48 h under Ar atmosphere and specimens were quenched in water at room temperature. Corrosion experiments were performed in cell culture medium under cell culture conditions. Cytocompatibility was evaluated by direct cell adhesion and live/dead staining tests. After T4 heat treatment, the amount of intermetallic phases is significantly decreased, which leads to significant improvement of corrosion properties by a very high factor (5-30). The results of live/dead staining reveal that the cells are mostly in viable state and homogenously distributed over the surface. The corrosion layer shows no cytotoxicity to primary human osteoblasts.
Proceedings Inclusion? Planned: A combination print-CD volume


Absorbable Filament Technologies: Wire-drawing to Enable Next-generation Medical Devices
Appropriate Corrosion-FatigueTesting of Magnesium Alloys for Temporary Bio-implant Applications
Computer Simulation of the Mechanical Behaviour of Implanted Biodegradable Stents in a Remodelling Artery
Degradation of MgF2-coated and Uncoated MgNd2 Specimens in Contact with Nasal Mucosa
Fabrication, Testing and Performance of Rare Earth-containing Magnesium Biodegradable Metals
In Vitro Corrosion and Cytocompatibility Properties of Mg-2Gd-X(Ag, Ca) Alloys
Influence of Precipitation Hardening in Mg-Y-Nd on Mechanical and Corrosion Properties
Magnesium-based Compression Screws
Magnesium Powder Injection Molding (MIM) of Orthopedic Implants for Biomedical Applications
Manufacturing of Osteosynthesis Systems Made of Magnesium Alloy AZ91
Monitoring Biodegradation of Magnesium Implants with Sensors
Plasma Surface Modification of Magnesium-Based and Related Biomaterials
Standardized Guidance for the Preclinical Evaluation of Absorbable Metal Implants
The Industrial Challenges of Manufacturing Bioabsorbable Magnesium
Understanding Corrosion-assisted Cracking of Magnesium Alloys for Bioimplant Applications

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