Extension of additive manufacturing to aerospace gas turbines promises enhanced design flexibility but calls for developments in process/alloy design. While powder-based e-beam processes show great potential, many nickel-base alloys currently used for rotating and stationary high temperature components exhibit severe cracking during processing, generally associated with solidification segregation, undesirable phases, remelt behavior, and hot cracking, all compounded by stresses that develop during the build. Mitigation of process-related cracking requires advancement on several fronts, generally including alloy design, powder production, and e-beam build strategies. In the work presented here, we examine new alloy compositions around conventional Mar-M 247. Using computational thermodynamics, test builds, and various characterization techniques (SEM, EBSD, EDS and S/TEM) we investigate segregation and phase constitution, tracking the results of alloy modifications from powder production through test builds with repetitive remelting cycles. Support from U.S. DOE-EERE-Advanced Manufacturing Office in partnership with ORNL-MDF at Ames Laboratory through contract no. DE-AC02-07CH11358.765.