A seamless integration of biomedical devices with a human body could enable a myriad of exciting applications in the field of diagnostic, drug-delivery, regenerative medicine and smart prosthetics. Indeed, the ability to impart active functionalities such as advanced sensing, computation and actuation through biomedical devices could restore or even augment the complex functionalities of a naturally evolved biological system. Yet, such integration is inherently challenging due to the geometrical, mechanical and material dichotomies between conventional biomedical devices and the human body. In general, my research strives to overcome these dichotomies by developing alternative device fabrication methods that are fundamentally free from the constraint of the conventional manufacturing technologies. Such approach leverages the synergistic integration of the unique properties of functional nanomaterials with the versatility of multi-scale microextrusion-based 3D printing to enable the creation of next-generation personalized biomedical devices.