|About this Abstract
||Materials Science & Technology 2012
||Surface Properties of Biomaterials III
||Bioactive Orthopaedic Coatings Based on Bioglass® 45S5/ Chitosan Composites Obtained by Electrophoretic Deposition
||Fatemehsadat Pishbin, Abdolreza Simchi, Viviana Mourino, James Gilchrist, Vehid Salih, Mary P. Ryan, Aldo R. Boccaccini
|On-Site Speaker (Planned)
Bioactive glass coatings are well-known candidates for improving biological adhesion between metallic orthopaedic implants and human tissue. Such glass coatings can be mechanically improved by using biocompatible polymers forming composite coatings. The biopolymer can also act as carrier of drugs and other bioactive molecules. This work presents results on the development of “soft” coatings based on natural biocompatible and biodegradable polysaccharides (chitosan) and bioactive glass (Bioglass<SUP>®</SUP> 45S5). Electrophoretic deposition (EPD) was employed to develop such composite coatings. EPD is a promising technique for co-deposition of organic and inorganic components at low temperatures on complex shaped substrates.Kinetics of deposition of chitosan and Bioglass<SUP>®</SUP> 45S5 from aqueous solutions on both planar and 3D porous metallic structures was investigated. Additionally EPD was applied to fabricate novel multifunctional coatings with drug release capability. Antibacterial agents were incorporated in the composite films and preliminary drug release, <I>in vitro</I> cellular and microbiological tests were conducted.
||Planned: None Selected