|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Advanced Materials in Dental and Orthopedic Applications
||Cellular Response of Escherichia Coli to Mg-2Zn-2Gd Alloy with Different Grain Structure: Mechanism of Disruption of Colonization
||Pramanshu Trivedi, K.C. Nune, R.D.K. Misra , A.K. Patel, K. Balani, R. Jayganthan
|On-Site Speaker (Planned)
We describe here, the grain size dependent bactericidal effect of magnesium alloy. In this context, Mg-2Zn-2Gd alloy that was subjected to multiaxial forging (MAF) to obtain different grain size in the range of ~44 Ám to ~710 nm. Contact angle measurements using goniometer and wettability were assessed with water, SBF, n-Hexane and DMEM. The antimicrobial activity and the mechanism of inhibition of Escherichia coli (E. coli) bacterial cell attachment were determined as a function of grain size. The higher surface energy of ultrafine-grained Mg-2Zn-2Gd alloy led to the release of more Mg+2 ions at an early stage, which consequently increased the pH of fluid in the vicinity of the implant, therefore producing unfavorable environment for the survival of bacteria. This led to damage of bacterial cell walls and reducing their adhesion. Furthermore, a significant degree of apatite formation was indication of high bioactivity in the ultrafine-grained alloy.
||Planned: Supplemental Proceedings volume