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Meeting 2018 TMS Annual Meeting & Exhibition
Symposium Biodegradable Materials for Medical Applications
Presentation Title H-2: Development of Biodegradable Operative Zinc Clips for Ligation
Author(s) Jeffrey Michael Brookins, Jan-Marten Seitz, Jeremy Goldman, Jaroslaw Drelich
On-Site Speaker (Planned) Jeffrey Michael Brookins
Abstract Scope A new generation of biodegradable metals may replace conventional permanent materials for surgical clips. Presently, there are no metallic bioabsorbable ligating clips commercially available; corrosion-resistant titanium and stainless steel clips are predominantly used for laparoscopic surgeries, as well as other ligating procedures. Zinc and other zinc-based alloys have recently gained attention for biodegradable implant applications due to their ideal corrosion rate and excellent biocompatibility; and are now being explored to replace permanent, corrosion-resistant clips. In this study, surgical clips made of high purity zinc were manufactured. On-going characterization of these novel clips include mechanical testing, burst pressure testing, and in vitro corrosion studies in simulated body fluid. Initial results indicate that an applied zinc clip can withstand 660 ± 30 mmHg of vessel pressure, compared to a physiologically expected 100 - 250 mmHg.
Proceedings Inclusion? Planned: Supplemental Proceedings volume

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Biocompatibility of Biodegradable Mg-Zn-Ca Metallic Glass
Biodegradable Borate Glass for Wound Healing and Bone Regeneration Implants via Boronizing
Biodegradable Mg-implants – Current Market Experiences
Biological Response of Surface Modified Mg-Sr Alloy for Orthopedic Applications
Comparative Study on Corrosion Behavior WE33 in Immersion and Polarization Influenced by Heat Treatment
Corrosion Properties of Mg-Ca-Gd Alloy Applied to Biodegradable Implants
Development of a Bioresorbable Vascular Scaffold for Treating Coronary Artery Disease: A Case Study
Development of a New Biodegradable Surgical Clip Made of a Magnesium Alloy: Evaluation of its Safety and Tolerability for Canine Cholecystectomy
Development of Porous and Biodegradable Hydroxyapatite/Mg Alloy Composite as Biodegradable Implants for Orthopaedic Applications
Effect of Additive Zinc on Mechanical Properties and Degradation Behavior of Magnesium
Fe-based Alloys: A New Class of High Strength Low-degradation Biodegradable Metals for Health Applications
Fundamentals of the Theory of Biodegradable Metals—Definition, Biodegradability and Biosafety Criteria and its Guidance on Material Design
H-1: Designing Polymeric Membranes for Medical Applications
H-2: Development of Biodegradable Operative Zinc Clips for Ligation
H-3: Long Term Biocompatibility of Zinc and its Alloys for Absorbable Vascular Scaffolds
H-4: Microstructural Evolution and Mechanical Properties of Zn-Ti alloys for Biodegradable Stent Applications
Influence of Casting on Microstructure and Corrosion of Mg-Ca-Zn Alloys for Biomedical Application
Is Corrosion Fatique Relevant for Biodegradable Magnesium Implants?
Mechanical and Corrosion Property Profile of Biodegradable, Open-porous Scaffolds Made of Sintered Magnesium Short Fibers
Mechanical Properties of Nanocrystalline Bioresorbable Fe-Mn Alloy
Metal Injection Molding (MIM) of Mg-alloys for Biomedical Applications
Microstructure and Mechanical Properties of Mg-Gd Alloys as Biodegradable Implant Materials
Microstructure Properties and In-vitro Degradation Behavior of the Bioresorbable Magnesium Alloy ZNdK100
Opportunities Offered by Zinc Alloys for Degradable Implants: Recent Trends and Developments
Osteosynthesis in a Growing Ovine Model using Bioresorbable Rare-earth-free Magnesium Screws
Osteosynthesis in an Osteoporotic Rat Model Using Magnesium-based Pins
Progress in Absorbable Wire Technology for Next Generation Devices
Resoloy – the Resorbable Mg Alloy for Stents
Study on Polylactide-coconut Fibre for Biomedical Applications
Surface Modification of Biomaterials by Plasma-based Technology
The Preparation of a Mg-Zn-Nd Alloy Wire and its Potential Application in Medicine
Visualisation of Implant Failure by Synchrotron Tomography
Where Do We Stand on Development of Ideal Biodegradable Zinc Material for Vascular Stenting?

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