|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||Local Drug Delivery Techniques for the Prevention of Implant-Associated Infections
||Rizhi Wang, Mehdi Mehdi Kazemzadeh-Narbat, Menghan Ma, Robert E. W. Hancock
|On-Site Speaker (Planned)
Prevention of implant-associated infections has been one of the main challenges in orthopaedic surgery. An ideal strategy to combat implant-associated infections would be prevention of infection at the site of the implant. There are two issues facing the local delivery of antibiotics through orthopaedic implants. The first one is avoiding antibiotic resistance; the second one is achieving antimicrobial activity without impairing peri-implant bone growth. In this presentation, we will discuss our latest progress in solving those issues. A unique group of cationic antimicrobial peptides has been selected for the local delivery through implant surfaces to avoid developing antibiotic resistance. Osteoconductive coatings such as calcium phosphate and titania nanotube coatings have been developed as the delivery media. Drug release analysis, cytotoxicity tests, and antimicrobial activity against both Gram-positive and Gram negative bacteria demonstrated that the local delivery technique could be a potential solution for the prevention of peri-implant infection in orthopaedics.