| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Biomaterials for Biomedical Implants
|
| Presentation Title |
Hemocompatibility and Biocompatibility Evaluation of an Mg-Ca-Sr Alloy for Vascular Stent Applications |
| Author(s) |
Sonia Ezenwajiaku, Vidhya Ramaswamy, Hunter B. Henderson, Josephine B. Allen, Michele V. Manuel |
| On-Site Speaker (Planned) |
Sonia Ezenwajiaku |
| Abstract Scope |
Motivated by magnesium’s biocompatibility, mechanical properties, and natural degradation, a range of medical applications have been investigated. In this study, we focus on using a Magnesium-Calcium-Strontium (Mg-Ca-Sr) alloy for vascular device applications. Limited research has been conducted on the biocompatibility and hemocompatibility of this alloy system with vascular cells, whole blood, and blood components. The present study evaluates the alloy's thromboresistance with blood components and interactions with vascular endothelial cells. We show that the alloy resists platelet adhesion, activation, hemolysis, and clotting processes. We also show endothelial cells exposed to alloy extract are highly proliferative, non-inflammatory, and migratory. Collectively, the data support Mg-Ca-Sr alloys in vascular applications, i.e., vascular stents, where contact with the endothelium and circulating blood is expected in addition to anti-thrombogenic function.
This work was partially performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Magnesium, Characterization |