|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Biological Materials Science
||The Influence of Plastic Deformation Mechanisms on the Collagen Formation in Osteoblast Cells
||Benay Uzer, Felipe Monte, Kamal R. Awad, Pranesh B Aswath, Venu G. Varanasi, Demircan Canadinc
|On-Site Speaker (Planned)
In many of biomedical applications the implant might get in direct contact with the bone cells where the osteogenesis needs to be stimulated. If osteoblasts can’t successfully attach on the implant surface the bone might resorb and implant can fail. In the current study the MC3T3 cells were cultured on the 316L stainless steel samples which were deformed up to three strain levels (5, 15 and 25%) to activate plastic deformation mechanisms (slip and twinning) in different volume fractions. The results showed a significant amount of collagen formation on the 25% deformed sample on which slip and twinning mechanisms were activated significantly. Their interaction has also increased the surface energy which would catalyze the deposition of ECM proteins. Overall the manipulation of the material’s microstructure would enhance cell response and as a result long lasting implants could be obtained which would eliminate additional surgical interventions.
||Planned: Supplemental Proceedings volume