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Meeting Materials Science & Technology 2012
Symposium Next Generation Biomaterials
Presentation Title Design and Testing of Magnetic Vascular Stents for Rapid Endothelialization
Author(s) Susheil Uthamaraj, Brandon J. Tefft, Janelle Y. Gooden, Jonathan Harburn, David R. Holmes, Robert D. Simari, Gurpreet S. Sandhu, Dan Dragomir-Daescu
On-Site Speaker (Planned) Susheil Uthamaraj
Abstract Scope Rapid endothelialization of cardiovascular stents by means of magnetic cell capture has the potential to enhance healing and to reduce the risk of restenosis. We designed and manufactured stents made of magnetizable 2205 duplex stainless steel (UNS S31803) to study the magnetic field strength required to capture endothelial cells labeled with superparamagnetic nanoparticles. To aid in the design, we used the finite element method to study stress and strain distributions and to ensure strain values do not exceed 30% during crimping and expansion. Stents magnetized with a permanent magnet exhibited magnetic fields in the range of 630 mG compared to 10 mG for non-magnetized stents as measured by a magnetoresistive probe. Furthermore, we observed that plastic deformation greatly reduced the magnetic field strength, but did not result in material fracture. Finally, endothelial cell capture studies revealed that approximately 310 cells/mm2 were attracted to the magnetized stents within 1-3 minutes.
Proceedings Inclusion? Planned: Post-meeting proceedings

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

3D Printed Doped β-TCP Scaffolds for Bone Tissue Engineering: Processing, Mechanical and Biological Property Characterization
Bioactive Scaffolds for Bone Regeneration
Biomimetic Nanoclay Nanocomposites in Bone Tissue Engineering
Ca-Aluminate as a Base for Biomaterials - An Overview
Calcium Phosphate Reinforced Ti for Load Bearing Implants
Cellular Interactions and Modulated Osteoblasts Functions Mediated by Protein Adsorption in New Generation of Hybrid Network Structure Elastomers
Characterization of Next-Generation Nickel-Titanium Rotary Endodontic Instruments
Combined AFM and 3-D Optical Microscopy of Cells and Biomaterials
Comparative Surface Characterization of Nitinol Alloys
Corrosion Behavior of MgxTi1-x Alloys Fabricated by Mechanical Alloying and Compaction Methods
Corrosion Behavior of Pulsed DC Microarc Oxidation Coated AZ31 Magnesium Alloy in Simulated Body Fluid
Cytocompatibility and Stimulated Osteoblasts Functions Induced by Graphene Oxide in Polymeric Biomaterials
Degradation and Biocompatibility Behavior of Surface Treated MgZnCa/nHA MMCs for Orthopedic Implants
Design and Testing of Magnetic Vascular Stents for Rapid Endothelialization
Effect of Cold Work and Aging on a Cobalt-Nickel Based Multiphase Alloy
Electro-Plasma Deposition & Characterization of Hydroxy-Apatite Coating
Enhancing the Wear Resistance and Osseo-Integration of Next Generation Beta Titanium Alloys For Orthopedic Implants
Freeze-Cast Preparation of Porous Bioceramics with Controlled Silver Release
Human Liver Cell Culturing in Porous Hydroxyapatite/Hydrogel Composites
In- Vitro Reconstruction of the Human Bone Marrow Niche in a Calcium Phosphate Bioreactor Core
Interfaces in Biomaterials: Characterization and First Principles Calculations
Manufacturing of Composite Fibrous Membranes for Biomedical and Energy Storage Applications
Mechanical and Chemical Stability of Silver Nano-Particles on Porous Substrates
Mechanical Properties of Bioactive Glass Scaffolds Fabricated by Robotic Deposition for the Regeneration of Load-Bearing Bone
Modification of NiTi Shape Memory Alloy Functional Properties Via Laser Processing: Proof of Concept
Multifunctional Protein Enabled Patterning on Ferroelectric Materials
Nanopore Topography Impacts the Performance of Tailored Amorphous Multi-Porosity (TAMP) Bioactive Scaffolds
Nanoscale Modification of Biomaterials to Control Cell Growth
Nature-Inspired Biomaterials for Bone Regeneration
Nature-Inspired Materials Design and Manufacturing
Non-Covalent Crosslinkers for Electrospun Chitosan Fibers
Novel 3D Bioceramic Scaffolds from Extrusion of Preceramic Polymers Containing Micro- and Nano-Sized Reactive Particles
Novel Generation of Particles and Capsules from Bubbles for Biomedical Engineering
Organic-Inorganic Scaffolds for Bone Substitute Applications
Parametric Studies on Femtosecond Laser Cutting of Ni-Ti Shape Memory Alloy
Phase Stability and Young’s Modulus of Ti-Cr-Sn-Zr Alloys
Polydimethylsiloxane Substrates with Tunable Elastic Modulus: Independent Control of Stiffness Over a Three Order-of-Magnitude Range
Porosity-Property Relationships in Bioceramics -- Beyond the Exponential Forms
Prediction of the Stress Distribution and the Coating Delamination in Cardiovascular Drug-Eluting Stent (DES) Medical Devices
Preparation of TiO2/HAp Bioactive Coatings by Micro Arc Oxidation (MAO) Method
Recruitment of Regulatory Lymphocytes for Periodontal Disease
Sol-Gel Preparation of Silica-Based Nano-Fibers for Biomedical Applications
Stability of Boron-Containing Titanium Alloys in Simulated Physiological Environments
Strengths of Solid State NMR to Investigate Substituted Hydroxyapatites
Surface Coating of Poly-D-L-Lactide/Nano-Hydroxyapatite Composite Scaffolds for Dexamethasone-Releasing Function and Wettability Enhancement
Transport Behavior in Controlled Release Coatings

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