|About this Abstract
||Materials Science & Technology 2011
||MS&T'11 Poster Session
||007 Direct Cytotoxicity Evaluation of 63s Bioactive Glass Nanoparticles Using Yeast Model and Human Chondrocyte Cells by Microcalorimetry
||Ali Doostmohammadi, Ahmad Monshi, Mohammad Hossein Fathi
|On-Site Speaker (Planned)
The cytotoxicity evaluation of 63S bioactive glass nanoparticles with yeast and human chondrocyte cells was carried out using isothermal micro-nano calorimetry (IMNC), which is a new method for studying cell/biomaterial interactions. Bioglass nanoparticles were made via sol-gel method. Elemental analysis was carried out by XRF. Amorphous structure of the glass was detected by XRD analysis. Finally, the cytotoxicity of bioactive glass nanoparticles with yeast and cultured human chondrocyte cells was evaluated using IMNC. The results confirmed the viability and proliferation of human chondrocyte cells in contact with 63S bioglass nanoparticles. Also the results indicated that yeast model which is much easier to handle, can be considered as a good proxy and can provide a rapid primary estimate of the ranges to be used in assays involving human cells. All of these results confirmed that IMNC is a convenient method which caters to measuring the cell-biomaterial interactions alongside the current methods.