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Meeting 2016 TMS Annual Meeting & Exhibition
Symposium Biological Materials Science Symposium
Presentation Title Transient Simulation of Low Volume Gravity Driven Flow in a Human Organ Mimicking Microfluidic Platform
Author(s) Kazi M. Tasneem, Christopher J. Long, James J. Hickman
On-Site Speaker (Planned) Kazi M. Tasneem
Abstract Scope Microfluidic body-on-a-chip systems enable the physical modeling of human physiological organ systems for drug testing and disease modeling. Incorporation of a rocking platform to recirculate fluid has enabled reduced medium volumes and the elimination of pumps and their associated issues. The microfluidic flow dynamics in a rocking system differ dramatically from those in a pumped system, due to time-dependent bidirectional flow profiles affected by the microfluidic device design and the tilting action. Specifically, the finite volumes of the device fluidic reservoirs produce first order differential equations for the flow rate through the device, affecting localized shear stresses. A hybrid model incorporating computational fluid dynamics with one analogous to electrical circuit simulation was developed for these microfluidic systems similar to those used in body-on-a-chip systems, such that both the time-dependent flow dynamics and localized shear stress profiles can be modeled to aid in their design to produce desired physiological microenvironments.
Proceedings Inclusion? Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)

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