Next generation surface modification techniques for titanium implants must exhibit excellent mechanical properties while also encouraging rapid osseointegration. Cold spray processing is a solid-state deposition method used to deposit dense metal coatings and has potential for surface coatings for biomedical applications. In this talk we report on the relationship between processing, microstructure characterization, and biological performance of titanium-hydroxyapatite biocomposite cold spray coatings. Coatings with varying composition of hydroxyapatite and titanium (20% HA, 50% HA, and functionally graded) were fabricated using high-pressure cold spray deposition. As-processed coatings were characterized using optical microscopy, scanning electron microscopy, x-ray diffraction, and contact angle goniometry. Adhesion strength of the coatings was measured using a tensile pull-off adhesion test. Cell morphology, viability, differentiation, and mineral deposition were investigated via in vitro cell culture assays. Finally, the bioactive nature of the coatings was examined using a simulated body fluid solution.