|About this Abstract
||Materials Science & Technology 2012
||Surface Properties of Biomaterials III
||Mass Transport, Heterogeneity and Cell Population Dynamics Modulate Tissue Regeneration Processes
||Kyriacos Zygourakis, Pauline Markenscoff
|On-Site Speaker (Planned)
A better understanding of the complex interplay between cell population dynamics and mass transport is necessary for overcoming the barriers that slow down the development of bioartificial tissues. We will use a multi-scale hybrid computational model developed by our group to study the dynamic behavior of heterogeneous cell populations growing in three-dimensional scaffolds under mass transfer limitations. Our simulation results reveal that cell differentiation or necrosis induced by limited availability of a nutrient of growth factor can lead to the formation of complex tissue architectures. The dynamics of pattern formation are also modulated by cell differentiation, apoptosis, scaffold heterogeneities, the initial spatial distribution of seed cells, time-dependent addition of the limiting nutrient or growth factor to the media and the hydrodynamics of the bioreactor used to grow the engineered tissues. Finally, we explore the effect of artificial vessels on the growth rates and structure of regenerated tissues.
||Planned: None Selected