|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Biodegradable Materials for Medical Applications
||Where Do We Stand on Development of Ideal Biodegradable Zinc Material for Vascular Stenting?
||Jaroslaw Drelich, Jeremy Goldman
|On-Site Speaker (Planned)
A possible breakthrough in the field of biodegradable metallic vascular stents was made in 2013 in our research team with the introduction of zinc and its alloys, which degrade at a nearly ideal rate of ~0.02 mm/year and are biocompatible. Our laboratories refined the composition and microstructure of several Zn alloys, which have promising mechanical properties, and conducted detailed fundamental studies with more than 100 rats on their biocompatibility, toxicity, and biodegradation. Our progress was possible due to a wire implantation model that we developed in 2012 to simulate the presence of a stent strut within the vascular space. The wire model allows for simplified investigations at the interface between the candidate metal and the arterial environment. In this presentation, we will review and summarize our study on Zn-based alloy formulation, their mechanical properties and behavior in vascular environment.
||Planned: Supplemental Proceedings volume