Guided by experimental tests of theory and practice, science has advanced rapidly in the past 500 years. Meanwhile, guided primarily by tradition and dogma, science education has remained largely medieval. Taking a research approach to teaching STEM subjects is now revealing principles and practices that achieve much better learning than traditional approaches. The combination of this research approach to instruction and modern information technology is setting the stage for a major advance in STEM education, an advance that can provide the relevant and effective science education for all students that is needed for the 21st century. Wieman will discuss the failures of traditional educational practices, even as used by “very good” teachers, and the successes of some new practices and technology that characterize this more effective approach, and how these results are consistent with findings from cognitive science.