Crystalline core-shell low dimensional structures, in particular II-VI semiconductors show interesting behavior at the nanoscale. Due to enhancement of some properties, they find applications in optics, solar cells, biosensing, coating etc. Thermo-mechanical behavior of these nanostructured materials become critical especially in these applications. In this study, we will focus on the thermo-mechanical properties of 0-,1-,2-dimensional core-shell CdS/ZnS as a prototypical II-VI system. Using molecular dynamics simulations with Tersoff type interatomic potentials, we investigate mechanical behavior at elevated temperatures by subjecting the model systems to tensile/compressive, shear, bending and biaxial mechanical loads to determine stress/strain behavior up to failure. We compare and contrast the response failure stresses in different dimensions, concentrations and core/shell geometries. We will also discuss the atomistic details events leading to failure – initiation and growth.