Imaging and microscopy combined with spectroscopy, diffraction, or other analytical methods, allow one to see and understand a real material in all of its complexity. The use of in situ or operando studies, for example using x-ray and electron microscopy, extends this out to 4D or 5D visualization of local behavior. However, as powerful as these individual approaches are, usually no single measurement provides all the information needed to understand a material. Integrated imaging offers a way to bridge across experimental and computational imaging capabilities and thus close the loop between design, simulation, synthesis, characterization, and analysis. In this talk I will give a overview of Argonne’ imaging initiative with examples related to nanostructures and materials for energy, that explore the way in which such an approach can address scientific challenges.