|About this Abstract
||2016 TMS Annual Meeting & Exhibition
||Bio Nano Interfaces and Engineering Applications
||How Do Nano and Microscale Surface Topographies Affect Bacterial Attachment? Designing a New Generation of Antimicrobial Surfaces
||Benjamin Hatton, Nicolas Lavielle, Dalal Asker
|On-Site Speaker (Planned)
The interaction between bacteria and surfaces is complex and the roles of nano- and micoscale topographies have not been clearly identified. Understanding these relationships is important due to the persistent problem of biomaterial infection rates (often nosocomial), and an increasing problem of antibiotic-resistant strains. I will show examples that shed light on the relationship between nanotopographies and bacterial surface attachment. We have generated nanotopographies using a templated co-assembly method, and with photolithographic etching.
An important factor to control bacterial attachment is with surface wettability. Herein we show that non-wetting, superhydrophobic surfaces can precisely allow or prevent bacterial cell attachment. Further, we have that surface microstructures can confine and stabilize a thin lubricant layer, for non-adhesive ‘slippery liquid-infused porous surfaces’ (SLIPS). We have demonstrated the effectiveness of such omniphobic surfaces to effectively prevent bacterial adhesion (30 days, continuous culture) and blood clot adhesion.
||Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)